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        2. DISEASE MOUSE MODELS

          Model animals, as an important tool for human disease research, aid in the investigation of disease mechanisms and the development of therapies. Mouse models, being the most extensively used model animals, are employed in a variety of areas, such as fundamental scientific research, drug discovery, preclinical evaluation, and clinical technology development. Mice have a close relationship with humans, advanced genetic manipulation, fast reproduction, and a clear genetic background. Gene editing technology can provide suitable disease models for study based on disease-related genes. GemPharmatech has produced numerous disease models using gene editing technologies, such as spontaneous tumor models, obesity models, diabetes models, Alzheimer's disease models, Parkinson's disease models, and so on. Through phenotypic analysis, GemPharmatech has also confirmed the incidence and development of numerous model-related phenotypes, providing solid support for the research of various diseases.

          Introducing GemPharmatech's Latest Strains: Unveiling the Future of Innovation


          Strain ID

          Strain Name

          Application

          T055223


          B6-Tg(hSOD1 G93A,hSOD1) 圖片1.png

          Genetic humanization, ALS disease

          T058996

          FAD4T-hTREM2 圖片1.png

          Genetic humanization, Alzheimer's disease

          T054322

          B6-hSNCA E46K A53T

          Genetic humanization, Parkinson's disease

          T056757

          B6-hCD36

          Genetic humanization, neuroinflammation

          T056002

          B6-Dmd Del45

          Duchenne muscular dystrophy, 45 exon deletion

          T055631

          B6-hDLL4

          Genetic humanization, oncology

          T056429

          B6-hCD34

          Genetic humanization, oncology

          T058753

          B6-hCEACAM5-Tg

          Genetic humanization, oncology

          T053316

          B6-hIL18R1/hIL18RAP

          Genetic humanization, oncology

          T037007

          B6-hCD47/hSIRPA 圖片1.png

          Genetic humanization, oncology

          T056010

          BALB/c-hCD44

          Genetic humanization, oncology

          T054198

          BALB/c-hGPC3

          Genetic humanization, oncology

          T054490

          BALB/c-hSEMA4D

          Genetic humanization, oncology

          T054543

          BALB/c-hHSA

          Genetic humanization, oncology

          T056432

          BALB/c-hTROP2 圖片1.png

          Genetic humanization, oncology

          T056011

          BALB/c-hCD44v6

          Genetic humanization, oncology

          T055714

          BALB/c-hCS1

          Genetic humanization, oncology

          T056083

          BALB/c-hLRRC15

          Genetic humanization, oncology

          T056430

          BALB/c-hNECTIN-4

          Genetic humanization, oncology

          T058266

          BALB/c-hTIGIT/hPVRIG

          Genetic humanization, oncology

          T054842

          BALB/c-hPD1/hPDL1/hTIGIT/hCD9 圖片1.png

          Genetic humanization, oncology

          T058749

          BALB/c-hPD1/hPDL1/hCD73/hCD39 圖片1.png

          Genetic humanization, oncology

          T009819


          BALB/c-hHER2 圖片1.png


          Genetic humanization, oncology

          T009813

          NCG-hHER2

          Genetic humanization, oncology

          T054081

          NOD-Scid-hNKp30

          Genetic humanization, oncology

          T056195

          B6-hIGHA1

          Genetic humanization, autoimmune disease


          T054583

          BALB/c-hIL1RL1

          Genetic humanization, autoimmune disease

          T054645

          BALB/c-hKLRB1

          Genetic humanization, autoimmune disease

          T003277

          BALB/c-hIL17A 圖片1.png

          Genetic humanization, autoimmune disease

          T053555

          BALB/c-hIL1β

          Genetic humanization, autoimmune disease

          T054186

          BALB/c-hTLR8

          Genetic humanization, autoimmune disease

          T055268

          BALB/c-hFcgRs/hCD47/hSIRPA 圖片1.png

          Genetic humanization, Fc end modification for antibody drugs, ADCC effect

          T058940

          BALB/c-hCD3EDG/hCD22

          Genetic humanization, CD3 bispecific antibody related

          T057420

          BALB/c-hCD73/hCD3EDG 

          Genetic humanization, CD3 bispecific antibody related

          T058817

          BALB/c-hGPRC5D/hCD3EDG 圖片1.png

          Genetic humanization, CD3 bispecific antibody related

          T059045

          BALB/c-hCD3EDG/hBCMA 圖片1.png

          Genetic humanization, CD3 bispecific antibody related

          T058351

          B6-Rosa26-hAGT 圖片1.png

          Genetic humanization, hypertension

          T058352

          B6-H11-hREN

          Genetic humanization, hypertension

          T054639

          B6-hCD200R1

          Genetic humanization, atherosclerosis research

          T058217

          B6-hAPOB-Tg

          Genetic humanization, hypercholesteremia and atherogenesis

          T058211

          B6-hAPOE-DGAT2-LE1 圖片1.png

          Genetic humanization, NASH

          T051403

          B6-Myh6-R404Q 圖片1.png

          Hypertrophic cardiomyopathy

          T027708

          B6-Mybpc3-KO

          hypertrophic cardiomyopathy or dilated cardiomyopathy

          T007085

          B6-Kras-G12D/wt; Lyz2-iCre

          Spontaneous lung cancer

          T053603

          kras-G12C 圖片1.png

          Kras-related spontaneous tumors

          T057165

          KPS 圖片1.png

          Spontaneous lung cancer

          T057162

          KS

          Spontaneous lung cancer